Drug interactions
Flibanserin + Molindone
Severity: Moderate
Flibanserin and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and hypotension, and both affect serotonergic and dopaminergic pathways. Combined use may add to CNS depression, with a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Flibanserin and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension, with theoretical serotonergic and dopaminergic pharmacodynamic overlap.
What to do
Monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel the patient about dizziness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Molindone?
MediHelp rates the interaction as moderate. Flibanserin and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and hypotension, and both affect serotonergic and dopaminergic pathways. Combined use may add to CNS depression, with a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Flibanserin and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel the patient about dizziness and driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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