Drug interactions
Flibanserin + Nafcillin
Severity: Moderate
Flibanserin and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower flibanserin exposure. Reduced flibanserin levels could lead to loss of its effect on hypoactive sexual desire.
What this interaction means in plain words
Flibanserin and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated metabolism of flibanserin by nafcillin.
What to do
Monitor for reduced response to flibanserin; consider an alternative antibiotic if feasible during prolonged nafcillin courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Nafcillin?
MediHelp rates the interaction as moderate. Flibanserin and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower flibanserin exposure. Reduced flibanserin levels could lead to loss of its effect on hypoactive sexual desire.
How serious is the interaction between Flibanserin and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to flibanserin; consider an alternative antibiotic if feasible during prolonged nafcillin courses.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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