Drug interactions
Flibanserin + Netupitant / palonosetron
Severity: Contraindicated
Flibanserin and Netupitant / palonosetron: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and can increase flibanserin exposure. This raises the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Netupitant / palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Netupitant inhibits CYP3A4, reducing flibanserin clearance.
What to do
Avoid; withhold flibanserin around netupitant dosing or use a different antiemetic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Netupitant / palonosetron?
MediHelp rates the interaction as contraindicated. Flibanserin and Netupitant / palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Netupitant is a moderate CYP3A4 inhibitor and can increase flibanserin exposure. This raises the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Netupitant / palonosetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; withhold flibanserin around netupitant dosing or use a different antiemetic.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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