Drug interactions
Flibanserin + Olanzapine
Severity: Moderate
Flibanserin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and can cause hypotension, so combined use may increase drowsiness, dizziness and syncope. Olanzapine is not a CYP3A4 inhibitor.
What this interaction means in plain words
Flibanserin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension.
What to do
Monitor for sedation and orthostatic hypotension. Counsel the patient about dizziness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Flibanserin with Olanzapine?
MediHelp rates the interaction as moderate. Flibanserin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and can cause hypotension, so combined use may increase drowsiness, dizziness and syncope. Olanzapine is not a CYP3A4 inhibitor.
How serious is the interaction between Flibanserin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension. Counsel the patient about dizziness and driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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