Drug interactions
Flibanserin + Remifentanil
Severity: Moderate
Flibanserin and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remifentanil is a potent short-acting opioid, and flibanserin adds to CNS depression and hypotension. This matters mainly in procedural or anesthetic settings where additive sedation and blood pressure drops may occur.
What this interaction means in plain words
Flibanserin and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic CNS depression and hypotensive effects.
What to do
Inform the anesthesia team that the patient takes flibanserin. Monitor sedation level and blood pressure and titrate remifentanil to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Flibanserin with Remifentanil?
MediHelp rates the interaction as moderate. Flibanserin and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remifentanil is a potent short-acting opioid, and flibanserin adds to CNS depression and hypotension. This matters mainly in procedural or anesthetic settings where additive sedation and blood pressure drops may occur.
How serious is the interaction between Flibanserin and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team that the patient takes flibanserin. Monitor sedation level and blood pressure and titrate remifentanil to effect.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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