Drug interactions
Flibanserin + Schisandra
Severity: Major
Flibanserin and Schisandra: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Schisandra constituents may inhibit CYP3A4 and could increase flibanserin exposure. Evidence is limited, but higher levels would raise the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Flibanserin and Schisandra can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Possible CYP3A4 inhibition by schisandra lignans; clinical magnitude is not well established.
What to do
Advise patients to avoid schisandra supplements while taking flibanserin; counsel about dizziness and fainting.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Schisandra, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Schisandra?
MediHelp rates the interaction as major. Flibanserin and Schisandra can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Schisandra constituents may inhibit CYP3A4 and could increase flibanserin exposure. Evidence is limited, but higher levels would raise the risk of hypotension, syncope and sedation.
How serious is the interaction between Flibanserin and Schisandra?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid schisandra supplements while taking flibanserin; counsel about dizziness and fainting.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
