Drug interactions
Flibanserin + Triazolam
Severity: Major
Flibanserin and Triazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a CYP3A4-metabolized benzodiazepine, and flibanserin adds sedation and may weakly inhibit CYP3A4. The combination can cause marked sedation, impaired alertness and syncope.
What this interaction means in plain words
Flibanserin and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression plus possible CYP3A4 inhibition by flibanserin raising triazolam exposure.
What to do
Avoid the combination where possible, or use the lowest triazolam dose and monitor for oversedation. Advise against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Triazolam?
MediHelp rates the interaction as major. Flibanserin and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triazolam is a CYP3A4-metabolized benzodiazepine, and flibanserin adds sedation and may weakly inhibit CYP3A4. The combination can cause marked sedation, impaired alertness and syncope.
How serious is the interaction between Flibanserin and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest triazolam dose and monitor for oversedation. Advise against alcohol and driving.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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