Drug interactions
Flibanserin + Trifluoperazine
Severity: Moderate
Flibanserin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine antipsychotic that causes sedation and hypotension, and flibanserin adds CNS depression and syncope risk. Serotonin syndrome or neuroleptic malignant syndrome are theoretical concerns when serotonergic and dopamine-blocking activities are combined.
What this interaction means in plain words
Flibanserin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension, with theoretical interplay between serotonergic modulation and dopamine blockade.
What to do
Monitor for oversedation, hypotension, hyperthermia, rigidity and mental status changes. Counsel the patient to avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Flibanserin with Trifluoperazine?
MediHelp rates the interaction as moderate. Flibanserin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine antipsychotic that causes sedation and hypotension, and flibanserin adds CNS depression and syncope risk. Serotonin syndrome or neuroleptic malignant syndrome are theoretical concerns when serotonergic and dopamine-blocking activities are combined.
How serious is the interaction between Flibanserin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, hypotension, hyperthermia, rigidity and mental status changes. Counsel the patient to avoid alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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