Drug interactions
Flibanserin + Triprolidine
Severity: Moderate
Flibanserin and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triprolidine is a sedating first-generation antihistamine, and flibanserin also causes somnolence. Together they may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Flibanserin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Triprolidine belongs to Respiratory.
Why it happens
Additive pharmacodynamic CNS depression from the antihistamine and flibanserin.
What to do
Advise the patient to avoid driving if drowsy. Consider a non-sedating antihistamine if an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Triprolidine
Frequently asked questions
Can I take Flibanserin with Triprolidine?
MediHelp rates the interaction as moderate. Flibanserin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triprolidine is a sedating first-generation antihistamine, and flibanserin also causes somnolence. Together they may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Flibanserin and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid driving if drowsy. Consider a non-sedating antihistamine if an antihistamine is needed.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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