Drug interactions
Flibanserin + Zaleplon
Severity: Moderate
Flibanserin and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is a sedative-hypnotic and flibanserin also causes somnolence. Combined use may increase sedation, dizziness and next-day impairment.
What this interaction means in plain words
Flibanserin and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Zaleplon belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel on additive sedation and avoid driving or hazardous tasks. Use the lowest effective hypnotic dose and monitor for impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Flibanserin with Zaleplon?
MediHelp rates the interaction as moderate. Flibanserin and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zaleplon is a sedative-hypnotic and flibanserin also causes somnolence. Combined use may increase sedation, dizziness and next-day impairment.
How serious is the interaction between Flibanserin and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving or hazardous tasks. Use the lowest effective hypnotic dose and monitor for impairment.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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