Drug interactions
Flibanserin + Zolpidem
Severity: Moderate
Flibanserin and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolpidem and flibanserin both cause sedation and dizziness. Together they may increase CNS depression and next-day impairment, including complex sleep behaviors and falls.
What this interaction means in plain words
Flibanserin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flibanserin belongs to Genitourinary; Zolpidem belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Counsel on additive sedation and avoid driving until response is known. Use the lowest effective zolpidem dose and monitor for impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flibanserin and Zolpidem, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Flibanserin with Zolpidem?
MediHelp rates the interaction as moderate. Flibanserin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zolpidem and flibanserin both cause sedation and dizziness. Together they may increase CNS depression and next-day impairment, including complex sleep behaviors and falls.
How serious is the interaction between Flibanserin and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving until response is known. Use the lowest effective zolpidem dose and monitor for impairment.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
