Drug interactions
Fluconazole + Indinavir
Severity: Minor
Fluconazole and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 substrate, and fluconazole modestly increases its exposure. This may raise the risk of indinavir adverse effects such as nephrolithiasis and hyperbilirubinemia, though the effect is generally small.
What this interaction means in plain words
Fluconazole and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluconazole inhibits CYP3A4, slightly reducing indinavir clearance.
What to do
No empirical dose change is normally required; ensure adequate hydration and monitor for renal and urinary symptoms of indinavir toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Indinavir?
MediHelp rates the interaction as minor. Fluconazole and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir is a CYP3A4 substrate, and fluconazole modestly increases its exposure. This may raise the risk of indinavir adverse effects such as nephrolithiasis and hyperbilirubinemia, though the effect is generally small.
How serious is the interaction between Fluconazole and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is normally required; ensure adequate hydration and monitor for renal and urinary symptoms of indinavir toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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