Drug interactions
Fluconazole + Kolanut
Severity: Minor
Fluconazole and Kolanut: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kola nut contains caffeine, which is metabolized mainly by CYP1A2. Fluconazole has a weak effect on caffeine clearance, so any increase in stimulant effects is likely small.
What this interaction means in plain words
Fluconazole and Kolanut have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluconazole may weakly inhibit CYP1A2-mediated caffeine metabolism.
What to do
No action is needed beyond advising patients to limit large amounts of kola nut or caffeine if they develop jitteriness, palpitations or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Kolanut?
MediHelp rates the interaction as minor. Fluconazole and Kolanut have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Kola nut contains caffeine, which is metabolized mainly by CYP1A2. Fluconazole has a weak effect on caffeine clearance, so any increase in stimulant effects is likely small.
How serious is the interaction between Fluconazole and Kolanut?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond advising patients to limit large amounts of kola nut or caffeine if they develop jitteriness, palpitations or insomnia.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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