Drug interactions
Fluconazole + Lithium
Severity: Moderate
Fluconazole and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium has been associated with QT prolongation and conduction abnormalities, mostly at higher concentrations or with predisposing factors. Fluconazole may add to the QT effect, so arrhythmia risk increases in vulnerable patients.
What this interaction means in plain words
Fluconazole and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Lithium belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; no established pharmacokinetic interaction.
What to do
Monitor ECG and electrolytes, and check serum lithium concentration to keep it within range. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Fluconazole with Lithium?
MediHelp rates the interaction as moderate. Fluconazole and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium has been associated with QT prolongation and conduction abnormalities, mostly at higher concentrations or with predisposing factors. Fluconazole may add to the QT effect, so arrhythmia risk increases in vulnerable patients.
How serious is the interaction between Fluconazole and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and check serum lithium concentration to keep it within range. Avoid adding other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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