Drug interactions
Fludarabine + Trastuzumab
Severity: Moderate
Fludarabine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab has been associated with more neutropenia and febrile neutropenia when given with myelosuppressive chemotherapy. Fludarabine is strongly myelosuppressive and immunosuppressive, so infection risk may be increased.
What this interaction means in plain words
Fludarabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludarabine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression and immunosuppression; the trastuzumab contribution is not fully explained.
What to do
Monitor blood counts and watch closely for fever and infection. Adjust the fludarabine dose or give supportive care such as growth factors according to neutrophil counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Belatacept + Fludarabine Major
- Dengue vaccine + Fludarabine Major
- Etrasimod + Fludarabine Major
- Fingolimod + Fludarabine Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Fludarabine with Trastuzumab?
MediHelp rates the interaction as moderate. Fludarabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab has been associated with more neutropenia and febrile neutropenia when given with myelosuppressive chemotherapy. Fludarabine is strongly myelosuppressive and immunosuppressive, so infection risk may be increased.
How serious is the interaction between Fludarabine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch closely for fever and infection. Adjust the fludarabine dose or give supportive care such as growth factors according to neutrophil counts.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
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