Drug interactions
Fludarabine + Ublituximab
Severity: Moderate
Fludarabine and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludarabine produces marked lymphopenia and ublituximab depletes B cells, so combined use increases the risk of serious and opportunistic infections.
What this interaction means in plain words
Fludarabine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludarabine belongs to Oncology; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion plus purine analogue-induced lymphocyte suppression.
What to do
Monitor blood counts and for infection, and use antimicrobial prophylaxis according to local protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Belatacept + Fludarabine Major
- Dengue vaccine + Fludarabine Major
- Etrasimod + Fludarabine Major
- Fingolimod + Fludarabine Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Fludarabine with Ublituximab?
MediHelp rates the interaction as moderate. Fludarabine and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludarabine produces marked lymphopenia and ublituximab depletes B cells, so combined use increases the risk of serious and opportunistic infections.
How serious is the interaction between Fludarabine and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection, and use antimicrobial prophylaxis according to local protocols.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
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