Drug interactions
Fludrocortisone + Fosinopril-hydrochlorothiazide
Severity: Moderate
Fludrocortisone and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and, with hydrochlorothiazide, can produce marked potassium loss. It also promotes sodium and water retention, opposing the antihypertensive effect.
What this interaction means in plain words
Fludrocortisone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium excretion and mineralocorticoid-driven sodium retention.
What to do
Monitor serum potassium and blood pressure regularly, and supplement potassium or adjust doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Fludrocortisone and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and, with hydrochlorothiazide, can produce marked potassium loss. It also promotes sodium and water retention, opposing the antihypertensive effect.
How serious is the interaction between Fludrocortisone and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly, and supplement potassium or adjust doses as required.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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