Drug interactions
Fludrocortisone + Indomethacin
Severity: Moderate
Fludrocortisone and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of peptic ulcer and GI bleeding. Fludrocortisone's mineralocorticoid effects may also promote fluid retention and worsen blood pressure control alongside indomethacin.
What this interaction means in plain words
Fludrocortisone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Corticosteroids impair mucosal repair while NSAIDs reduce protective prostaglandins; both promote sodium and fluid retention.
What to do
Consider gastroprotection with a proton pump inhibitor and monitor blood pressure, edema and GI symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Indomethacin?
MediHelp rates the interaction as moderate. Fludrocortisone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of peptic ulcer and GI bleeding. Fludrocortisone's mineralocorticoid effects may also promote fluid retention and worsen blood pressure control alongside indomethacin.
How serious is the interaction between Fludrocortisone and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor and monitor blood pressure, edema and GI symptoms.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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