Drug interactions
Fludrocortisone + Isavuconazonium
Severity: Moderate
Fludrocortisone and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and may modestly raise fludrocortisone exposure, increasing mineralocorticoid effects such as hypokalemia and fluid retention. Corticosteroids may also add to infection risk in patients treated for invasive fungal disease, although fludrocortisone has weak immunosuppressive activity.
What this interaction means in plain words
Fludrocortisone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, reducing fludrocortisone metabolism.
What to do
Monitor blood pressure, potassium and fluid status, and reduce the fludrocortisone dose if excess mineralocorticoid effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Fludrocortisone with Isavuconazonium?
MediHelp rates the interaction as moderate. Fludrocortisone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and may modestly raise fludrocortisone exposure, increasing mineralocorticoid effects such as hypokalemia and fluid retention. Corticosteroids may also add to infection risk in patients treated for invasive fungal disease, although fludrocortisone has weak immunosuppressive activity.
How serious is the interaction between Fludrocortisone and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and fluid status, and reduce the fludrocortisone dose if excess mineralocorticoid effects occur.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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