Drug interactions
Fludrocortisone + Ketoprofen
Severity: Moderate
Fludrocortisone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone's mainly mineralocorticoid activity also causes fluid retention, which NSAIDs can worsen.
What this interaction means in plain words
Fludrocortisone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from reduced prostaglandin protection and corticosteroid effects, plus additive sodium and fluid retention.
What to do
Use the lowest effective ketoprofen dose and duration, and monitor blood pressure, edema, and GI symptoms. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Ketoprofen?
MediHelp rates the interaction as moderate. Fludrocortisone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone's mainly mineralocorticoid activity also causes fluid retention, which NSAIDs can worsen.
How serious is the interaction between Fludrocortisone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ketoprofen dose and duration, and monitor blood pressure, edema, and GI symptoms. Consider gastroprotection in high-risk patients.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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