Drug interactions
Fludrocortisone + Levofloxacin
Severity: Moderate
Fludrocortisone and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids taken with fluoroquinolones raise the chance of tendinitis and tendon rupture. Fludrocortisone has mainly mineralocorticoid activity at usual doses, so the added risk is probably smaller than with glucocorticoids but still applies.
What this interaction means in plain words
Fludrocortisone and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive adverse effects on tendon structure and healing from corticosteroid and fluoroquinolone exposure.
What to do
Counsel patients to stop levofloxacin and seek review if tendon pain occurs. Consider another antibiotic in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fludrocortisone and Levofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Levofloxacin?
MediHelp rates the interaction as moderate. Fludrocortisone and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids taken with fluoroquinolones raise the chance of tendinitis and tendon rupture. Fludrocortisone has mainly mineralocorticoid activity at usual doses, so the added risk is probably smaller than with glucocorticoids but still applies.
How serious is the interaction between Fludrocortisone and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop levofloxacin and seek review if tendon pain occurs. Consider another antibiotic in older patients.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
