Drug interactions
Fludrocortisone + Nimodipine
Severity: Minor
Fludrocortisone and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has little CYP3A4 induction activity and a meaningful reduction in nimodipine levels is unlikely. Fludrocortisone causes sodium retention that may oppose antihypertensive effects of nimodipine.
What this interaction means in plain words
Fludrocortisone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Nimodipine belongs to Cardiovascular.
Why it happens
Theoretical weak CYP3A4 induction; mineralocorticoid effect may oppose blood pressure lowering.
What to do
No dose change is required; monitor blood pressure and fluid status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Nimodipine?
MediHelp rates the interaction as minor. Fludrocortisone and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has little CYP3A4 induction activity and a meaningful reduction in nimodipine levels is unlikely. Fludrocortisone causes sodium retention that may oppose antihypertensive effects of nimodipine.
How serious is the interaction between Fludrocortisone and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor blood pressure and fluid status.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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