Drug interactions
Fludrocortisone + Oxaprozin
Severity: Moderate
Fludrocortisone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which NSAIDs may worsen, with potential for edema and raised blood pressure.
What this interaction means in plain words
Fludrocortisone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID depletion of protective gastric prostaglandins plus corticosteroid impairment of mucosal healing; additive sodium retention.
What to do
Use the lowest NSAID dose for the shortest time and consider a proton pump inhibitor. Monitor blood pressure, edema, potassium and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Oxaprozin?
MediHelp rates the interaction as moderate. Fludrocortisone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which NSAIDs may worsen, with potential for edema and raised blood pressure.
How serious is the interaction between Fludrocortisone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time and consider a proton pump inhibitor. Monitor blood pressure, edema, potassium and signs of GI bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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