Drug interactions
Fludrocortisone + Quinidine
Severity: Minor
Fludrocortisone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine could modestly raise fludrocortisone exposure through P-glycoprotein inhibition. A clinically relevant effect is unlikely.
What this interaction means in plain words
Fludrocortisone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux of fludrocortisone.
What to do
No routine action is needed. Monitor blood pressure and potassium, as fludrocortisone-induced hypokalemia can itself add to quinidine proarrhythmic risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Quinidine?
MediHelp rates the interaction as minor. Fludrocortisone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine could modestly raise fludrocortisone exposure through P-glycoprotein inhibition. A clinically relevant effect is unlikely.
How serious is the interaction between Fludrocortisone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor blood pressure and potassium, as fludrocortisone-induced hypokalemia can itself add to quinidine proarrhythmic risk.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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