Drug interactions
Fludrocortisone + Ritonavir
Severity: Moderate
Fludrocortisone and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and P-glycoprotein inhibitor that can raise corticosteroid exposure. This may cause fluid retention, hypertension, hypokalemia and, with prolonged use, Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Fludrocortisone and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by ritonavir reduces fludrocortisone clearance.
What to do
Monitor blood pressure, edema and serum potassium, and lower the fludrocortisone dose if signs of excess appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Fludrocortisone with Ritonavir?
MediHelp rates the interaction as moderate. Fludrocortisone and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a strong CYP3A4 inhibitor and P-glycoprotein inhibitor that can raise corticosteroid exposure. This may cause fluid retention, hypertension, hypokalemia and, with prolonged use, Cushingoid effects and adrenal suppression.
How serious is the interaction between Fludrocortisone and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium, and lower the fludrocortisone dose if signs of excess appear.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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