Drug interactions
Fludrocortisone + Sulindac
Severity: Moderate
Fludrocortisone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs both damage the gastrointestinal mucosa, and using them together raises the chance of gastric irritation, ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which may blunt blood pressure control and worsen edema when combined with an NSAID.
What this interaction means in plain words
Fludrocortisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects, plus additive sodium and fluid retention.
What to do
Use the lowest effective sulindac dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for GI bleeding symptoms, edema and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Sulindac?
MediHelp rates the interaction as moderate. Fludrocortisone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs both damage the gastrointestinal mucosa, and using them together raises the chance of gastric irritation, ulceration and bleeding. Fludrocortisone also causes sodium and fluid retention, which may blunt blood pressure control and worsen edema when combined with an NSAID.
How serious is the interaction between Fludrocortisone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sulindac dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for GI bleeding symptoms, edema and blood pressure.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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