Drug interactions
Fludrocortisone + Tolfenamic acid
Severity: Moderate
Fludrocortisone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use raises the risk of gastric irritation, ulceration and bleeding. NSAIDs also cause sodium retention and may blunt blood pressure control in patients on fludrocortisone.
What this interaction means in plain words
Fludrocortisone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury and additive sodium and fluid retention.
What to do
Limit NSAID dose and duration, consider a proton pump inhibitor, and monitor blood pressure, edema and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Fludrocortisone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Fludrocortisone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use raises the risk of gastric irritation, ulceration and bleeding. NSAIDs also cause sodium retention and may blunt blood pressure control in patients on fludrocortisone.
How serious is the interaction between Fludrocortisone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit NSAID dose and duration, consider a proton pump inhibitor, and monitor blood pressure, edema and signs of GI bleeding.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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