Drug interactions
Fludrocortisone + Vardenafil
Severity: Minor
Fludrocortisone and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has little clinically relevant CYP3A4 induction at replacement doses, so no meaningful change in vardenafil exposure is expected. A clinically important interaction is not established.
What this interaction means in plain words
Fludrocortisone and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Vardenafil belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 induction is theoretical; no established mechanism.
What to do
No routine action is needed; assess response to vardenafil as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fludrocortisone and Vardenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Vardenafil?
MediHelp rates the interaction as minor. Fludrocortisone and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has little clinically relevant CYP3A4 induction at replacement doses, so no meaningful change in vardenafil exposure is expected. A clinically important interaction is not established.
How serious is the interaction between Fludrocortisone and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; assess response to vardenafil as usual.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
