Drug interactions
Fludrocortisone + Verapamil
Severity: Moderate
Fludrocortisone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise fludrocortisone exposure through CYP3A4 and P-glycoprotein inhibition, while corticosteroids may weakly induce CYP3A4 and lower verapamil levels. Raised mineralocorticoid effect can cause fluid retention, hypokalemia and hypertension, which oppose verapamil's effect.
What this interaction means in plain words
Fludrocortisone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and P-glycoprotein, raising fludrocortisone levels, while fludrocortisone may weakly induce CYP3A4.
What to do
Monitor blood pressure, edema and serum potassium. Adjust the fludrocortisone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Verapamil?
MediHelp rates the interaction as moderate. Fludrocortisone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise fludrocortisone exposure through CYP3A4 and P-glycoprotein inhibition, while corticosteroids may weakly induce CYP3A4 and lower verapamil levels. Raised mineralocorticoid effect can cause fluid retention, hypokalemia and hypertension, which oppose verapamil's effect.
How serious is the interaction between Fludrocortisone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium. Adjust the fludrocortisone dose according to response.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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