Drug interactions
Fludrocortisone + Zafirlukast
Severity: Minor
Fludrocortisone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may modestly reduce the metabolic clearance of fludrocortisone. This could enhance mineralocorticoid effects such as fluid retention, hypertension and hypokalemia.
What this interaction means in plain words
Fludrocortisone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP3A4-mediated fludrocortisone metabolism by zafirlukast.
What to do
Monitor blood pressure, edema and serum potassium when starting or stopping zafirlukast. Adjust the fludrocortisone dose if signs of excess mineralocorticoid effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fludrocortisone and Zafirlukast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Zafirlukast?
MediHelp rates the interaction as minor. Fludrocortisone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may modestly reduce the metabolic clearance of fludrocortisone. This could enhance mineralocorticoid effects such as fluid retention, hypertension and hypokalemia.
How serious is the interaction between Fludrocortisone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium when starting or stopping zafirlukast. Adjust the fludrocortisone dose if signs of excess mineralocorticoid effect appear.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
