Drug interactions
Flunisolide inhaled + Itraconazole
Severity: Moderate
Flunisolide inhaled and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase systemic exposure to flunisolide, because systemically absorbed drug is cleared by CYP3A4. Prolonged co-therapy could cause systemic corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Flunisolide inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces systemic clearance of flunisolide.
What to do
Monitor for signs of hypercortisolism with prolonged use. Consider an alternative inhaled corticosteroid such as beclomethasone if long-term azole therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Flunisolide inhaled with Itraconazole?
MediHelp rates the interaction as moderate. Flunisolide inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase systemic exposure to flunisolide, because systemically absorbed drug is cleared by CYP3A4. Prolonged co-therapy could cause systemic corticosteroid effects such as adrenal suppression.
How serious is the interaction between Flunisolide inhaled and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism with prolonged use. Consider an alternative inhaled corticosteroid such as beclomethasone if long-term azole therapy is needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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