Drug interactions
Flunisolide inhaled + Ribociclib
Severity: Minor
Flunisolide inhaled and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flunisolide is metabolized by CYP3A4, and systemic exposure from the inhaled route is low. Ribociclib may raise systemic corticosteroid levels slightly, with a small chance of systemic corticosteroid effects.
What this interaction means in plain words
Flunisolide inhaled and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, reducing flunisolide clearance.
What to do
Usually no change is needed; monitor for signs of corticosteroid excess if used long term at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Flunisolide inhaled with Ribociclib?
MediHelp rates the interaction as minor. Flunisolide inhaled and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flunisolide is metabolized by CYP3A4, and systemic exposure from the inhaled route is low. Ribociclib may raise systemic corticosteroid levels slightly, with a small chance of systemic corticosteroid effects.
How serious is the interaction between Flunisolide inhaled and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; monitor for signs of corticosteroid excess if used long term at high doses.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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