Drug interactions
Flunisolide inhaled + Voriconazole
Severity: Moderate
Flunisolide inhaled and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise systemic exposure to inhaled flunisolide. Systemic corticosteroid effects such as adrenal suppression or Cushingoid features are possible with prolonged use.
What this interaction means in plain words
Flunisolide inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of flunisolide, increasing systemic exposure.
What to do
Monitor for systemic corticosteroid effects during prolonged coadministration, and consider dose reduction of flunisolide or an alternative steroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Flunisolide inhaled with Voriconazole?
MediHelp rates the interaction as moderate. Flunisolide inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise systemic exposure to inhaled flunisolide. Systemic corticosteroid effects such as adrenal suppression or Cushingoid features are possible with prolonged use.
How serious is the interaction between Flunisolide inhaled and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects during prolonged coadministration, and consider dose reduction of flunisolide or an alternative steroid.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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