Drug interactions
Fluorouracil + Fondaparinux
Severity: Moderate
Fluorouracil and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil can cause myelosuppression and thrombocytopenia, which raises the risk of bleeding in patients on anticoagulants. The risk is greatest during nadir periods after chemotherapy.
What this interaction means in plain words
Fluorouracil and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluorouracil belongs to Oncology; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia; no direct pharmacokinetic interaction with fondaparinux.
What to do
Monitor platelet counts regularly and hold or reduce anticoagulation if platelets drop significantly. Watch for bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Fluorouracil
Frequently asked questions
Can I take Fluorouracil with Fondaparinux?
MediHelp rates the interaction as moderate. Fluorouracil and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil can cause myelosuppression and thrombocytopenia, which raises the risk of bleeding in patients on anticoagulants. The risk is greatest during nadir periods after chemotherapy.
How serious is the interaction between Fluorouracil and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly and hold or reduce anticoagulation if platelets drop significantly. Watch for bleeding signs.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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