Drug interactions
Fluorouracil + Hydroxycarbamide
Severity: Moderate
Fluorouracil and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the bone marrow, so combined use can intensify neutropenia and thrombocytopenia. Mucositis and infection risk may also increase.
What this interaction means in plain words
Fluorouracil and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluorouracil belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppression and cytotoxicity affecting DNA synthesis.
What to do
Monitor complete blood counts regularly and adjust doses according to cytopenias. Provide supportive care as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Fluorouracil with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Fluorouracil and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the bone marrow, so combined use can intensify neutropenia and thrombocytopenia. Mucositis and infection risk may also increase.
How serious is the interaction between Fluorouracil and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses according to cytopenias. Provide supportive care as needed.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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