Drug interactions
Fluoxetine + Flurbiprofen
Severity: Moderate
Fluoxetine and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine impairs platelet aggregation through serotonin depletion, and with flurbiprofen the risk of upper GI bleeding is increased. Fluoxetine also inhibits CYP2C9 and may modestly raise flurbiprofen exposure.
What this interaction means in plain words
Fluoxetine and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction with NSAID mucosal injury, and fluoxetine inhibition of CYP2C9-mediated flurbiprofen metabolism.
What to do
Consider a proton pump inhibitor for patients at elevated GI risk and use the lowest effective flurbiprofen dose. Monitor for signs of bleeding and NSAID adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Flurbiprofen?
MediHelp rates the interaction as moderate. Fluoxetine and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine impairs platelet aggregation through serotonin depletion, and with flurbiprofen the risk of upper GI bleeding is increased. Fluoxetine also inhibits CYP2C9 and may modestly raise flurbiprofen exposure.
How serious is the interaction between Fluoxetine and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for patients at elevated GI risk and use the lowest effective flurbiprofen dose. Monitor for signs of bleeding and NSAID adverse effects.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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