Drug interactions
Fluoxetine + Fluticasone-salmeterol
Severity: Moderate
Fluoxetine and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and salmeterol may add to QT effects and lower potassium. Together they may modestly increase arrhythmia risk, particularly with higher doses or electrolyte disturbance.
What this interaction means in plain words
Fluoxetine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist-induced hypokalemia.
What to do
Monitor ECG in patients with cardiac disease or other QT-prolonging drugs, and correct potassium and magnesium. Do not exceed recommended salmeterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Fluoxetine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and salmeterol may add to QT effects and lower potassium. Together they may modestly increase arrhythmia risk, particularly with higher doses or electrolyte disturbance.
How serious is the interaction between Fluoxetine and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac disease or other QT-prolonging drugs, and correct potassium and magnesium. Do not exceed recommended salmeterol doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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