Drug interactions
Fluoxetine + Fluvastatin
Severity: Minor
Fluoxetine and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine inhibits CYP2C9 to a modest degree and may raise fluvastatin concentrations. This could increase statin adverse effects such as myopathy, though clinical reports are limited.
What this interaction means in plain words
Fluoxetine and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Fluvastatin belongs to Cardiovascular.
Why it happens
Fluoxetine inhibits CYP2C9, reducing fluvastatin metabolism.
What to do
No routine dose change is needed. Monitor for muscle symptoms and use the lowest effective fluvastatin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Fluvastatin?
MediHelp rates the interaction as minor. Fluoxetine and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine inhibits CYP2C9 to a modest degree and may raise fluvastatin concentrations. This could increase statin adverse effects such as myopathy, though clinical reports are limited.
How serious is the interaction between Fluoxetine and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for muscle symptoms and use the lowest effective fluvastatin dose.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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