Drug interactions
Fluoxetine + Galantamine
Severity: Moderate
Fluoxetine and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine is partly metabolized by CYP2D6, and fluoxetine inhibits this enzyme, which can raise galantamine levels. Higher exposure may increase cholinergic effects such as nausea, vomiting and bradycardia.
What this interaction means in plain words
Fluoxetine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Fluoxetine inhibits CYP2D6, reducing galantamine metabolism.
What to do
Monitor for nausea, vomiting, bradycardia and other cholinergic effects, and titrate galantamine cautiously. Reduce the dose if tolerability problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Fluoxetine with Galantamine?
MediHelp rates the interaction as moderate. Fluoxetine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine is partly metabolized by CYP2D6, and fluoxetine inhibits this enzyme, which can raise galantamine levels. Higher exposure may increase cholinergic effects such as nausea, vomiting and bradycardia.
How serious is the interaction between Fluoxetine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, vomiting, bradycardia and other cholinergic effects, and titrate galantamine cautiously. Reduce the dose if tolerability problems occur.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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