Drug interactions
Fluoxetine + Gliclazide
Severity: Moderate
Fluoxetine and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may enhance the glucose-lowering effect of sulfonylureas and has been associated with hypoglycemia in diabetic patients. Fluoxetine also inhibits some CYP enzymes involved in gliclazide metabolism.
What this interaction means in plain words
Fluoxetine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Gliclazide belongs to Endocrine.
Why it happens
Improved insulin sensitivity from SSRIs plus possible CYP2C9/CYP2C19 inhibition raising gliclazide levels.
What to do
Monitor blood glucose when fluoxetine is started, adjusted or stopped. Lower the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Gliclazide?
MediHelp rates the interaction as moderate. Fluoxetine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine may enhance the glucose-lowering effect of sulfonylureas and has been associated with hypoglycemia in diabetic patients. Fluoxetine also inhibits some CYP enzymes involved in gliclazide metabolism.
How serious is the interaction between Fluoxetine and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluoxetine is started, adjusted or stopped. Lower the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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