Drug interactions
Fluoxetine + Glyburide-metformin
Severity: Moderate
Fluoxetine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can improve insulin sensitivity and lower blood glucose, which may add to the effect of glyburide-metformin. Hypoglycemia has been reported with SSRIs in patients receiving antidiabetic drugs.
What this interaction means in plain words
Fluoxetine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering; fluoxetine may also weakly inhibit CYP2C9, which could raise glyburide levels.
What to do
Monitor blood glucose more often when fluoxetine is started, adjusted or stopped. Lower the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fluoxetine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can improve insulin sensitivity and lower blood glucose, which may add to the effect of glyburide-metformin. Hypoglycemia has been reported with SSRIs in patients receiving antidiabetic drugs.
How serious is the interaction between Fluoxetine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when fluoxetine is started, adjusted or stopped. Lower the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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