Drug interactions
Fluoxetine + Ibrutinib
Severity: Moderate
Fluoxetine and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and increases bleeding risk, and SSRIs such as fluoxetine also reduce platelet serotonin uptake and impair hemostasis. Together they may raise the risk of bruising and clinically significant hemorrhage.
What this interaction means in plain words
Fluoxetine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function (BTK inhibition by ibrutinib and reduced platelet serotonin by fluoxetine).
What to do
Monitor for bleeding signs such as bruising, melena and epistaxis, and review other antithrombotic drugs. Consider an alternative antidepressant in patients with a high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Ibrutinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Fluoxetine with Ibrutinib?
MediHelp rates the interaction as moderate. Fluoxetine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and increases bleeding risk, and SSRIs such as fluoxetine also reduce platelet serotonin uptake and impair hemostasis. Together they may raise the risk of bruising and clinically significant hemorrhage.
How serious is the interaction between Fluoxetine and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs such as bruising, melena and epistaxis, and review other antithrombotic drugs. Consider an alternative antidepressant in patients with a high bleeding risk.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
