Drug interactions
Fluoxetine + Insulin degludec-liraglutide
Severity: Moderate
Fluoxetine and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can enhance glucose lowering and may increase the risk of hypoglycemia in patients on insulin or GLP-1 agonists. Glucose control can also fluctuate when the antidepressant is started or stopped.
What this interaction means in plain words
Fluoxetine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Serotonergic effects may improve insulin sensitivity and alter glucose regulation, producing an additive hypoglycemic effect.
What to do
Monitor blood glucose more often when fluoxetine is started, changed or stopped. Lower the insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Fluoxetine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can enhance glucose lowering and may increase the risk of hypoglycemia in patients on insulin or GLP-1 agonists. Glucose control can also fluctuate when the antidepressant is started or stopped.
How serious is the interaction between Fluoxetine and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when fluoxetine is started, changed or stopped. Lower the insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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