Drug interactions
Fluoxetine + Ivosidenib
Severity: Major
Fluoxetine and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval and fluoxetine has some QT liability, so the combination may raise the risk of serious arrhythmia. Ivosidenib is also a CYP3A4 inducer and may modestly lower exposure to some fluoxetine-metabolizing pathways.
What this interaction means in plain words
Fluoxetine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluoxetine belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Additive QT prolongation; ivosidenib enzyme induction may alter fluoxetine exposure.
What to do
Prefer an alternative antidepressant with less QT effect. If the combination is unavoidable, monitor ECG and electrolytes regularly and follow ivosidenib QT dose-reduction guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Fluoxetine with Ivosidenib?
MediHelp rates the interaction as major. Fluoxetine and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval and fluoxetine has some QT liability, so the combination may raise the risk of serious arrhythmia. Ivosidenib is also a CYP3A4 inducer and may modestly lower exposure to some fluoxetine-metabolizing pathways.
How serious is the interaction between Fluoxetine and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antidepressant with less QT effect. If the combination is unavoidable, monitor ECG and electrolytes regularly and follow ivosidenib QT dose-reduction guidance.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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