Drug interactions
Fluoxetine + Meloxicam
Severity: Moderate
Fluoxetine and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs increase the risk of gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9, which may modestly raise meloxicam concentrations and add to the risk.
What this interaction means in plain words
Fluoxetine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction and mucosal injury, plus CYP2C9 inhibition by fluoxetine reducing meloxicam clearance.
What to do
Avoid in patients at high GI risk or add a proton pump inhibitor. Monitor for bleeding signs and use the lowest effective meloxicam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Meloxicam?
MediHelp rates the interaction as moderate. Fluoxetine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs increase the risk of gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9, which may modestly raise meloxicam concentrations and add to the risk.
How serious is the interaction between Fluoxetine and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients at high GI risk or add a proton pump inhibitor. Monitor for bleeding signs and use the lowest effective meloxicam dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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