Drug interactions
Fluoxetine + Metformin-pioglitazone
Severity: Minor
Fluoxetine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may enhance insulin sensitivity and has been associated with hypoglycemia in patients on antidiabetic drugs. Fluoxetine also inhibits CYP2C9 and CYP2D6, which are not main routes for pioglitazone. The overall effect is generally mild.
What this interaction means in plain words
Fluoxetine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Serotonergic effects on glucose regulation add to antidiabetic action.
What to do
Monitor blood glucose when starting or stopping fluoxetine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Fluoxetine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine may enhance insulin sensitivity and has been associated with hypoglycemia in patients on antidiabetic drugs. Fluoxetine also inhibits CYP2C9 and CYP2D6, which are not main routes for pioglitazone. The overall effect is generally mild.
How serious is the interaction between Fluoxetine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluoxetine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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