Drug interactions
Fluoxetine + Metformin-repaglinide
Severity: Minor
Fluoxetine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may enhance insulin sensitivity and lower blood glucose, occasionally leading to hypoglycemia in patients on antidiabetic drugs. It also weakly inhibits CYP2C9 and CYP3A4, which could modestly raise repaglinide levels.
What this interaction means in plain words
Fluoxetine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering effect, with possible weak CYP inhibition affecting repaglinide.
What to do
Monitor blood glucose when fluoxetine is started, stopped, or changed in dose and adjust antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Fluoxetine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine may enhance insulin sensitivity and lower blood glucose, occasionally leading to hypoglycemia in patients on antidiabetic drugs. It also weakly inhibits CYP2C9 and CYP3A4, which could modestly raise repaglinide levels.
How serious is the interaction between Fluoxetine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluoxetine is started, stopped, or changed in dose and adjust antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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