Drug interactions
Fluoxetine + Nateglinide
Severity: Moderate
Fluoxetine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide is partly metabolized by CYP2C9, which fluoxetine inhibits, so nateglinide levels may rise. This could increase the risk of hypoglycemia.
What this interaction means in plain words
Fluoxetine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated nateglinide metabolism by fluoxetine.
What to do
Monitor blood glucose closely when fluoxetine is started or stopped and reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Fluoxetine with Nateglinide?
MediHelp rates the interaction as moderate. Fluoxetine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide is partly metabolized by CYP2C9, which fluoxetine inhibits, so nateglinide levels may rise. This could increase the risk of hypoglycemia.
How serious is the interaction between Fluoxetine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when fluoxetine is started or stopped and reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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