Drug interactions
Fluoxetine + Ofloxacin
Severity: Moderate
Fluoxetine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroxetine can prolong the QT interval, and ofloxacin may add to it. The combination can raise arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Fluoxetine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check for other QT-prolonging drugs and correct electrolyte disturbances. Obtain an ECG in higher-risk patients or choose an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Ofloxacin?
MediHelp rates the interaction as moderate. Fluoxetine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroxetine can prolong the QT interval, and ofloxacin may add to it. The combination can raise arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Fluoxetine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for other QT-prolonging drugs and correct electrolyte disturbances. Obtain an ECG in higher-risk patients or choose an alternative antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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