Drug interactions
Fluoxetine + Oxcarbazepine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive risk of hyponatremia/SIADH when an SSRI is combined with oxcarbazepine.
Mechanism of action
Pharmacodynamic: both can impair water handling and promote SIADH-related hyponatremia.
Clinical management
Check serum sodium at baseline and within 2–4 weeks of initiation or dose change, then periodically; monitor for headache, confusion, seizures; modify therapy if sodium falls.
Drug reference
References
- Trileptal (oxcarbazepine) Prescribing Information — FDA Label
- Prozac (fluoxetine) Prescribing Information – Hyponatremia/SIADH — FDA Label
- Hyponatremia associated with psychotropic medications — UpToDate
Frequently asked questions
Can I take Fluoxetine with Oxcarbazepine?
The interaction is rated: Moderate. Additive risk of hyponatremia/SIADH when an SSRI is combined with oxcarbazepine.
How serious is the interaction between Fluoxetine and Oxcarbazepine?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Fluoxetine and Oxcarbazepine managed?
Check serum sodium at baseline and within 2–4 weeks of initiation or dose change, then periodically; monitor for headache, confusion, seizures; modify therapy if sodium falls.
Why do Fluoxetine and Oxcarbazepine interact?
Pharmacodynamic: both can impair water handling and promote SIADH-related hyponatremia.
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